原创 血液畅通的 较高端人类

【写在最后】

许多科普读物称小肠是最长的器官。但事实上，血管才是真正最长的。虽然中学生物课本未明确血管是器官，但阐明了器官定义：由两种或以上不同类型组织构成，行使特定功能，承担生物体内一定工作。

血管完全符合此定义。组织学上，其管壁由不同组织构成的同心层组成：内膜包含内皮细胞层及薄层结缔组织；中膜为中间的肌肉/弹性层，含平滑肌和弹性组织；外膜主要是外层纤维结缔组织。神经组织在血管中虽不占主导，但参与调节平滑肌与痛觉。

因此医学上，血管与胃、肠、膀胱、肾等具有较大内腔的结构同属管状器官。

所以，最长的器官并非小肠，而是血管。

参考资料

[1] Ross R. Cell biology of atherosclerosis[J]. Annual review of physiology, 1995, 57(1): 791-804.

[2] Rafieian-Kopaei M, Setorki M, Doudi M, et al. Atherosclerosis: process, indicators, risk factors and new hopes[J]. International journal of preventive medicine, 2014, 5(8): 927.

[3] Furie B, Furie B C. Mechanisms of thrombus formation[J]. New England Journal of Medicine, 2008, 359(9): 938-949.

[4] Friedman M, Van den Bovenkamp G J. The pathogenesis of a coronary thrombus[J]. The American journal of pathology, 1966, 48(1): 19.

[5] Sprague A H, Khalil R A. Inflammatory cytokines in vascular dysfunction and vascular disease[J]. Biochemical pharmacology, 2009, 78(6): 539-552.

[6] Assessment R. Major lipids, apolipoproteins, and risk of vascular disease[J]. Jama, 2009, 302(18): 1993-2000.

[7] Sawabe M. Vascular aging: from molecular mechanism to clinical significance[J]. Geriatrics & gerontology international, 2010, 10: S213-S220.

[8] Bao C, Yang Z, Li Q, et al. Aerobic endurance exercise ameliorates renal vascular sclerosis in aged mice by regulating PI3K/AKT/mTOR signaling pathway[J]. DNA and cell biology, 2020, 39(2): 310-320.

[9] Camelo C, Luschnig S. Cells into tubes: Molecular and physical principles underlying lumen formation in tubular organs[M]//Current Topics in Developmental Biology. Academic Press, 2021, 143: 37-74.

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